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By Jannes Doppenberg, Piet van der Aar
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Extra resources for Dynamics in Animal Nutrition
Preventive effects of the probiotic Escherichia coli strain Nissle 1917 on acute secretory diarrhea in a pig model of intestinal infection. Digestive Disease & Science 51: 724-731. , 2005. Neonatal antibiotic treatment alters gastrointestinal tract developmental gene expression and intestinal barrier transcriptome. Physiological Genomics, 23: 235-245. , 2008. Early administration of probiotics alters bacterial colonization and limits diet-induced gut dysfunction and severity of necrotizing enterocolitis in preterm pigs.
G. , 2004). By contrast, duodenal and jejunal 36 Dynamics in animal nutrition Dynamics in animal nutrition Various immunomodulatory cells CD4+ T lymphocytes Various cells (incl. IEC cells) TNFα IL-1β IL-4 IL-6 IL-10 IL-13 TGF-β TEER (-/+) PCP (+/-) TEER (-) PCP (+) TEER (-) PCP (+) TEER (-) PCP (+) Claudin-1 (+) Claudin-2 (-) Protective against barrier and TJ changes induced by IFNγ ? Claudin-2 (-) Occludin (-) TJ strand numbers and depths (-) ERK or PKC Akt ? PI3K NFκB, MLCK NFκB, MLCK, PKA Pinocytosis of TJ proteins Rho kinase, MLC (occludin, claudin-1) phosphorylation Claudin-2 (-) Tight junction changes2 Intra-cellular signalling3 2TJ: trans-epithelial electrical resistance; PCP: para-cellular permeability.
Heat induction of heat shock protein 25 requires cellular glutamine in intestinal epithelial cells. American Journal of Physiology, Cell Physiology 291: C290-C299. P. , 2004. Weaning is associated with an upregulation of expression of inflammatory cytokines in the intestine of piglets. Journal of Nutrition 134: 641-647. , 1997. Factors influencing the structure and function of the small intestine in the weaned pig: A review. Livestock Production Science 51: 215-236. , 2004. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis.
Dynamics in Animal Nutrition by Jannes Doppenberg, Piet van der Aar