Download PDF by Serge Gauthier, Philip Scheltens, Jeffrey L. Cummings: Alzheimer's Disease and Related Disorders Annual 5
By Serge Gauthier, Philip Scheltens, Jeffrey L. Cummings
This quantity serves as a development file on state of the art study within the box of Alzheimer's disorder and different kinds of dementia, yet with an emphasis on issues which are acceptable to scientific perform. during this most modern installment, Serge Gauthier, Philip Scheltens and Jeffrey Cummings disguise a number of the rising remedies for Alzheimer's affliction, together with statins, GAG minetics, and immunotherapy, in addition to using hormonal remedy and bizarre anti-psychotic brokers within the remedy of alternative similar dementias. Chapters also will summarize the present knowing of the pathophysiology of light cognitive impairment in addition to learn into tau pathologies.
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Riemenschneider M, Wagenpfeil S, Vanderstichele H, et al. Phosphotau/total tau ratio in cerebrospinal fluid discriminates Creutzfeldt–Jakob disease from other dementias. Mol Psychiatry 2003;8:343–347. 47. Hampel H, Buerger K, Zinkowski R, et al. Measurement of phosphorylated tau epitopes in the differential diagnosis of Alzheimer disease: a comparative cerebrospinal fluid study. Arch Gen Psychiatry 2004; 61:95–102. 48. Hampel H, Buerger K, Kohnken R, et al. Tracking of Alzheimer’s disease progression with cerebrospinal fluid tau protein phosphorylated at threonine 231.
Older studies either ignore this domain entirely, or use measures that have little sensitivity to ECF. Some more recent studies include executive measures. e. verbal fluency, digit-symbol substitution, or Weschler Adult Intelligence Scale (Revised) (WAIS-R) similarities – and the Direct Assessment of Functional Status (DAFS) in AD cases. 21 reported that ECF measures add variance to functional outcomes above that attributed to ‘general’ cognitive measures, but the additional variance explained was relatively small.
40 GOLD STANDARD The majority of the above-mentioned studies have been obtained in groups of patients where the diagnosis has been obtained clinically. e. 17 The NINCDS/ADRDA (National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer’s Disease and Related Disorders Association) criteria for AD have a high sensitivity but a moderately high specificity. 56 Most published studies were performed in specialized tertiary referral settings with selected patient groups. 35,57 More studies are needed in large primary and secondary referral centers to obtain an 02-Chapter 2 5 8/31/05 11:09 AM Page 25 CSF MARKERS FOR DIAGNOSIS 25 insight into how to use CSF Aβ42, tau, and Ptau in an elderly population in clinical practice.
Alzheimer's Disease and Related Disorders Annual 5 by Serge Gauthier, Philip Scheltens, Jeffrey L. Cummings