New PDF release: AIDS and Heart Disease
By Ronald R. Watson
The 1st connection with gather the most recent examine and experiences at the remedy and pathogenesis of center ailment in AIDS sufferers, this reference makes an attempt to enhance the prognosis, administration, and treatment of HIV-associated center failure by way of learning the lengthy results of immunosuppression and opportunistic and viral an infection, in addition to cofactors affecting middle disorder akin to drug-related cardiotoxicity, cocaine abuse, and dietary deficiencies on cardiac functionality.
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The results are shown in Figure 6. Nuclear translocation of NF-κB was seen most clearly with cocaine and gp120 together. Mast cells primed with IL-1 β or TNF-α produce more proinflammatory cytokines than mast cells activated via the FcεRI alone. In patients with HIV infection, monocyte activation induces production of IL-1 and TNFα, and a monocyte-mast cell axis may exist that potentiates inflammatory responses. These data suggest that this in vitro phenomenon may have important in vivo biological consequences.
J Mol Cell Cardiol 2000; 32(12):2115–2129. 6. Schmitz G, Herr AS, Rothe G. T-lymphocytes and monocytes in atherogenesis. Herz 1998; 23:168–177. 7. Ross R. Rous-Whipple Award Lecture. Atherosclerosis: a defense mechanism gone awry. Am J Pathol 1993; 143:987–1002. 8. Ross R. Atherosclerosis—an inflammatory disease. N Engl J Med 1999; 340:115–126. 9. Kelley JL, Chi DS, Abou-Auda W, Smith JK, Krishnaswamy G. The molecular role of mast cells in atherosclerotic cardiovascular disease. Mol Med Today 2000; 6(8): 304–308.
This is supported by the report that a positive correlation exists between the number of adherent cells and the degree of AIDS and Heart disease 28 Figure 8 Unifying hypothesis regarding the role of mast cells, endothelial cells, and macrophages in the pathogenesis of HIV- and cocaineassociated atherogenesis and vasculopathy. Refer to text for detailed discussions. endothelial disturbance (42). The apoptosis of endothelial cells can lead to a procoagulant environment, leading to atherothrombotic disease and vasculopathy.
AIDS and Heart Disease by Ronald R. Watson